How often Tapentadol can be taken

Never take the next dose sooner than directed. For IR tablets, this typically
means leaving at least 4 hours between doses. Taking doses too close
together increases the risk of serious breathing problems and overdose.
Missed dose guidance

If you miss a dose of an immediate‑release tablet, take it when you
remember, but skip it if your next scheduled dose is near. Do not double
up. For extended‑release forms, follow your doctor’s written plan
exactly.
Tapentadol for Nerve Pain and Chronic Pain

One reason doctors consider Tapentadol for nerve pain is its norepinephrine
reuptake inhibition. This additional action sets it apart from many
other opioids.